Of continuous blood purification treatment of sepsis progress.doc

 PAGE \* MERGEFORMAT 12 Of continuous blood purification treatment of sepsis progress [Keywords:] continuous blood purification Sepsis is the difficulty of today’s critical care medicine and research focus that can lead to multiple organ failure, is one of the main causes of death. With the use of continuous blood purification technology to improve the treatment success rate is possible. A sepsis The incidence of sepsis continues to grow each year trend analysis of the reasons include population aging, interventional therapy and there is an increase in invasive care, abuse of antibiotics has allowed resistant strains increased, cancer, diabetes, chemotherapy, radiotherapy, immunosuppressive agents applications, as well as the increase in the number of infections in hospitals. Invasion of sepsis infection site mainly urinary tract, gastrointestinal tract, respiratory tract and skin. The most common pathogens are mainly E. coli, Pseudomonas aeruginosa, Staphylococcus aureus and so on. 1.1 refers to the concept of sepsis, pathogenic microorganisms or their toxins invade the blood circulation arising from systemic inflammatory response, is a clinical syndrome [1]. 1.2 diagnostic criteria [2] 1.2.1 Sepsis Diagnostic in 1991 ACCP / SCCM definitions, by infection-induced systemic inflammatory response, both of the following four in two, diagnosis can be established: (1) temperatureamp;gt; 38 ℃ or amp;lt;36 ℃ ; (2) heart rate amp;quot;90 times / min; (3) respiration rateamp;quot; 20 times / min or PaCO2 amp;lt;32 mmHg; (4) WBCamp;gt; 12 * 109 / L or amp;lt;4 * 109 / L, immature rod-shaped neutral PMN amp;quot;0.10. 1.2.2 Diagnosis of severe sepsis performance in addition to the above, but also with low perfusion, high metabolism and clinical manifestations of coagulation abnormalities: (1) hypoxemia (PaO2/FiO2 ≤ 300 mmHg); (2) oliguria (5 ml / h); (3) lactic acidosis (amp;gt; 2 mmol / L); (4) thrombocytopenia (amp;lt;100 * 109 / L) and prothrombin time extend