Of different doses of urokinase in the treatment of acute myocardial infarction.docVIP

 PAGE \* MERGEFORMAT 3 Of different doses of urokinase in the treatment of acute myocardial infarction [Keywords:] myocardial infarction; Urokinase; thrombolytic therapy; side effects [Abstract] Objective To understand the different doses of urokinase (UK) intravenous infusion in acute myocardial infarction (AMI) in patients with the efficacy and bleeding complications were observed. Methods 61 cases of AMI patients in line with WHO diagnostic criteria for AMI, no thrombolytic contraindications were randomly assigned to low-dose group and high-dose thrombolytic thrombolytic group. Of low-dose thrombolysis in 31 patients, to 600,000 u UK dissolved in 5% glucose solution 100 ml solution infusion finished within 30 min; high-dose thrombolytic group, 30 cases to 1.5 million u UK dissolved in 5% glucose 100 ml the solution within 30 min infusion END; other two sets of the same basic treatment. Each group of patients with thrombolytic therapy started within 3 h electrocardiogram inspected once every 30 min, after regular inspection; beginning to the onset of thrombolytic therapy within 24 h once every 2 h of serum CK, CK-MB, onset 48 h determined the last time. Observe the heart rate, heart rate, blood pressure, chest pain, change and vomit, sputum, urine, skin, mucous membrane bleeding signs. The results of low-dose thrombolytic group bleeding complications 3.23%, lower than the high-dose thrombolytic therapy group 20%, after a comparative analysis of the difference was significant (P amp;lt;0.05), in which two groups of gastrointestinal bleeding, blood sputum, the incidence of hematuria and the comparison of P amp;lt;0.05. Two groups of vascular recanalization rate, re-infarction rate, the incidence of severe complications, mortality similar, there was no significant difference (Pamp;gt; 0.05). Conclusion 600,000 u Treatment of AMI infusion of urokinase in particular, visceral bleeding complications significantly reduced the incidence of bleeding, efficacy, relia