Of nitric oxide on the role of the different uterine smooth muscle during pregnancy.doc

 PAGE \* MERGEFORMAT 11 Of nitric oxide on the role of the different uterine smooth muscle during pregnancy Keywords:: Nitric oxide uterine pregnancy NO is found in 80 years as a vascular endothelium-derived relaxing factor (endothelium-derived relaxing factor, EDRF), by L-arginine (L-arginine) with O2 in the nitric oxide synthase (niric oxide synthase, NOS) the role of the next generation of vascular smooth muscle has an important regulatory role, thus affecting vascular tone, blood flow and blood pressure [1]. Currently considered, NO is closely related with the uterine smooth muscle activity, especially for the pregnant uterus, NO level change by affecting the cyclic guanosine monophosphate (cGMP) acting on the uterine smooth muscle, thus affecting the contractions. NOS activity within the uterus NOS is the rate-limiting enzyme NO synthesis, its activity and NO levels are directly related. NOS including inducible NOS (iNOS), endothelial NOS (eNOS), neuronal NOS (nNOS) 3 isomers. Immunohistochemical staining has confirmed that a number of targeted pregnant animals and human myometrium, cervix, there are different NOS activity in placental tissues, using RT-PCR, further the different heterogeneous types of NOS were analyzed. NOS activity in the uterus of pregnant mice were as follows: uterine smooth muscle layer of mainly iNOS, followed by eNOS, while NOS activity in the second trimester myometrium the highest since started to decline to pre-term labor iNOS decreased 80%, eNOS by 50%; cervix of three kinds of organizations exist NOS isoforms during pregnancy in order to iNOS-based, full-pregnancy iNOS stability, and the more muscle iNOS activity is low, increased rapidly and reached the peak before labor, postpartum gradually decreased, eNOS and nNOS than iNOS activity is low, and the entire did not change significantly before and after pregnancy and childbirth, such differences in different stages of gestation and uterine NOS activity in uterine activity