Of chemokines and their receptors in cancer research.docVIP

 PAGE \* MERGEFORMAT 16 Of chemokines and their receptors in cancer research Author: Ren Yong, Chen Shousong, Qiman Li, Xiong Liping [Abstract] In recent years, chemokines and their receptors in tumor invasion and metastasis of the role of more and more attention, as molecular biology, molecular immunology and related technology development, more and more of chemokines and their receptors found in the study further in-depth, chemokines gene therapy and genetic vaccine applications is expected to become the new therapeutic strategies and means. [Keywords:] Chemotactic factor; chemokine receptor; tumor; Transfer Tumor invasion and metastasis is a major cause of death in patients with cancer, on the mechanism of tumor metastasis is not clear, the various possible factors that are still exploring. In recent years, chemokines (chemokines) and the chemokine receptor (chemokine receptors) in tumor invasion and metastasis of more and more people’s attention and that it may become a new target for cancer therapy, this article on this issue are reviewed. A chemotactic factor and chemokine receptor Chemokines, also known as chemical chemokine (chemoattractant cytokines), is a group of cells and inflammatory cells that have a variety of biological functions of the small molecule bioactive peptide, relative molecular mass of 8 000 ~ 10 000 (including 70 ~ 100 amino acid residues). Is now found at least more than 60 chemokines, cytokines belonging to a super-family. According to their molecular structure, amino acid cysteine (cysteine, C) residues sequence of sub-four classes: CXC (α ), CC (β ), C (γ ), CX3C (δ ) chemokines. CXC family again, depending on whether there is glutamic acid - leucine - arginine (ELR) motif are divided into two categories: ELR  CXC chemokines and the non-ELR  CXC chemokines. Studies indicate, ELR  CXC chemokines are effective blood vessel growth factors, such as interleukin (L)  8, growth related oncogene α (Groα ), growth related