Of nitric oxide synthase heme oxygenase and the relationship between liver cancer research.doc

 PAGE \* MERGEFORMAT 3 Of nitric oxide synthase heme oxygenase and the relationship between liver cancer research [Keywords:], nitric oxide synthase; heme oxygenase; primary liver cancer [Abstract] nitric oxide synthase and heme oxygenase with the occurrence and development of primary liver cancer and metastasis are closely related to this article on the progress of research in this area are reviewed. [Keywords:] nitric oxide synthase; heme oxygenase; primary liver cancer A family of nitric oxide synthase (nitricoxide synthase, NOS) is the endogenous biosynthetic enzymes [1 ~ 21], NOS has two forms: structured (cNOS) and inducible (iNOS), cNOS mainly in vascular endothelial cells , nerve cells and platelets, etc., with the cell membrane related to the non-active way to exist in the cytoplasm, dependent on Ca2 calmodulin, can be a variety of hormones, chemical and mechanical factors acting on cells, and activation [20], nitric oxide nitrogen can be fed back into cNOS inhibition of its activity. iNOS can induce a variety of cells generated, including myocardial cells, liver cells, nerve cells, microglia cells, neutrophils, vascular endothelial and smooth muscle cells [4]. iNOS can be endotoxin, interferon-γ , IL -1, IL -2 and tumor necrosis factor-α -induced, glucocorticoid, tumor necrosis factor-β , IL -4 and IL -10 inhibits iNOS transcription [2 ]. Under normal circumstances, cNOS produces NO concentration of 10 ~ 12 mmol, while the concentration of NO generated after iNOS activation of up to 9 ~ 10 mol [20,21]. Nitric oxide synthase by nitric oxide play a physiological and pathological role. NO in vivo as a highly reactive free radicals, both second messengers and the role of neurotransmitters, while an effect molecule-mediated regulation, including inhibition of platelet adhesion and basic maintenance of blood pressure, alveolar blood perfusion and ventilation of the match, long-term synaptic inhibition, penis straighten out, the glomeruli and bone marrow