Of prenatal stress on offspring hippocampal CA3 area of synaptic plasticity.docVIP

 PAGE \* MERGEFORMAT 10 Of prenatal stress on offspring hippocampal CA3 area of synaptic plasticity [Abstract] Objective To study the prenatal effects of stress on synaptic plasticity. Methods In this study, three-dimensional metrology of advanced prenatal stress were observed in female offspring hippocampal CA3 synaptic ultrastructure changes. Results Late prenatal stress can cause offspring postsynaptic density (Postsynaptic dlensity, PSD) thickness, (P amp;lt;0.001) PSD surface density (the PSD surface area per unit volume, SV) increased (P amp;lt;0.05), synaptic active zone extended (P amp;lt;0.05). Synaptic density (the numberical density per unit volume of synapses, Nv) decreased (P amp;lt;0.001). Conclusion prenatal stress may give rise to offspring hippocampal CA3 area changes in synaptic plasticity, which synapse functionality may be long-term impact. [Keywords:] prenatal stress; hippocampus; Synapse; plasticity The effect of prenatal stress on synaptic plasticity in the hippocampal CA3 region of the offspring [Abstract] Objective To investigate the effect of prenatal stress on synaptic plasticity of the developing hippocampal CA3 region in offspring, synaptic ultrastructure in the CA3 area was examined by stereological morphometric techniques. The results showed: there was greater thickness of PSD (P amp;lt;0.001 ) and longer synaptic active zone (P amp;lt;0.05) in late prenatal stress group, compared with the control group. The PSD surface area per unit volume (Sv) was remarkblely bigger than the control group (P amp;lt;0.05) and the numberical density per unit volume of synapses (Nv) also significantly decreased (P amp;lt;0.001). These results suggest that prenatal stress (PNS) can induce the change of the synaptic plasticity of the CA3 area in offspring, in the absence of any experimental manipulation, which may long-term modify synaptic efficacy. [Keywords:] prenatal stress; hippocampus; synapse; plasticity The normal development of the hipp