Of taurine on rat retinal ultrastructure injury in.docVIP

 PAGE \* MERGEFORMAT 15 Of taurine on rat retinal ultrastructure injury in 【Key Words】, taurine; N Abstract: Objective To observe the effect of taurine on N-methyl D-aspartate (NmethylDaspartate, NMDA) excitotoxicity caused by the organizational structure and ultrastructure of rat retinal injury in rats. Method in the vitreous cavity of rat eyes injected per 5μl 4mmol / L NMDA excitotoxicity caused by retinal damage model, 20 adult male SD rats were randomly divided into four groups: normal control group; NMDA group; NMDA taurine intervention group (intraperitoneal injection of 25mg/kg Taurine); phosphate buffered saline (PBS) control group. Vitreous after injection 4d, measuring the total thickness and the inner retinal thickness and retinal ultrastructure using TEM. Results NMDA to the total thickness of the retina in rats, especially the thickness of the inner retinal thinning (P lt;0001), ultrastructure shows the kernel layer and ganglion cell layer neurons degeneration changes, 25mg/kg Taurine intervention can effectively protect the retina organizational structure, weaken the NMDA induced retinal ultrastructure injury. Conclusion of taurine in the body can effectively protect the NMDA induced retinal tissue structure and ultrastructure damage. Keywords:: taurine; N-methyl D-aspartate; excitotoxicity; retina; ultrastructure Protective effects of taurine against retinal ultrastructural damage on rats Abstract: Objective To observe whether taurine has protective effects against NmethylDaspartate (NMDA) induced excitototxicity, especially in retinal histo pathological structure and ultrastructure in rat.Methods A rat model of retinal excitotoxicity injury induced by intravitreal injection of 5μl 4mmol / L NMDA in one eye . Twenty adult male SpragueDawley rats were divided into four groups: normal control, intravitreal injection of PBS control, NMDA group, NMDA injection and taurine treated group (intraperitoneal injection with 25m