Olmesartan endothelial function in patients with essential hypertension and renal function in.docVIP

 PAGE \* MERGEFORMAT 4 Olmesartan endothelial function in patients with essential hypertension and renal function in [Keywords:] vascular endothelial Can secrete a variety of vascular endothelial vasoactive substances to regulate vascular tone and structure to maintain the balance between coagulation and fibrinolysis, and hypertension, atherosclerosis and other diseases is closely related to the occurrence and development [1]. This study by measuring plasma endothelin -1 (ET-1), a nitric oxide (NO) and urinary microalbumin (U-MALB), urinary β 2-microglobulin (β 2-MG), of essential hypertension Patients with vascular endothelial function and renal function changes and the intervention of the role of olmesartan are reported below. 1 Data and methods 1.1 General Information May-August 2007 Cardiology in our hospital out-patient and hospitalization with mild to moderate essential hypertension 40 patients (treatment group), male 22 cases, female 18 cases; average age (63.2 ± 15.2) years of age. Are ruled out chronic congestive heart failure and chronic kidney insufficiency. 40 cases of healthy adults as a control group, male 22 cases, female 18 cases; average age (62.9 ± 16.1) years of age. 1.2 Methods (1) Delivery Methods: Hypertensive patients to stop taking the original half-life of five antihypertensive drugs and then entered clinical trials. Give Olmesartan (made in Shanghai) 20 mg oral, 1 time / d, were treated for 4 weeks. (2) determination of indicators: the treatment group in clinical trials, medication 4 weeks before and after the mining and venous blood and urine using radioimmunoassay ET-1 levels, nitrate reductase Determination of NO level, adsorption measured U-MALB and radioimmunoassay determination of urinary β 2-MG. Detection kit according to the instructions requested. Determination of the control group, only one time. 1.3 Statistical analysis All data are mean ± standard deviation (x ± s) indicated. Using t test. 2 Results Olmesarta