Olanzapine and clozapine treatment of schizophrenia Comparative Study.docVIP

 PAGE \* MERGEFORMAT 6 Olanzapine and clozapine treatment of schizophrenia Comparative Study [Abstract] Objective: To explore olanzapine’s efficacy and safety of the treatment of schizophrenia. Methods: 80 patients with schizophrenia were randomly assigned to olanzapine group and 40 patients in the clozapine group double-blind controlled study, the use of Positive and Negative Syndrome Scale (PANSS) and side effects scale (TESS) in the treatment of 8 weeks before and after treatment were not assessed the efficacy and adverse reactions. RESULTS: The olanzapine group and the clozapine group were reduced rate PANSS : 47.0% olanzapine group, clozapine group, 41.7%; clinical efficacy of olanzapine group was 90.0%, 92.4% clozapine group; olanzapine group and the clozapine group was no statistical difference between the effect of significance. TESS assessment of adverse effects of olanzapine group than clozapine group. Conclusion: Olanzapine is a safe and effective antipsychotic treatment of schizophrenia negative, positive symptoms and clozapine as effective, but poor reaction less. [Keywords:] Schizophrenia; olanzapine; clozapine Olanzapine are atypical antipsychotics, can improve all aspects of psychopathology, improve the quality of life of patients, and less adverse reactions [1]. Now olanzapine and clozapine in a randomized controlled study to evaluate the Austrian mirtazapine treatment of schizophrenia and safety. 1 Subjects and methods 1.1 Case study taken from December 2007 to April 2008 in our hospital mental patients, in line with CCMD-3 diagnostic criteria for schizophrenia, no major body and nervous system diseases, into the group before the blood, urine, liver function, biochemistry, ECG, EEG were normal in 80 patients. randomly divided into two groups according to admission were treated with olanzapine and clozapine treatment. 1.2 Study group with administration of olanzapine, the initial dose of 5 mg / d, 2 days to 10 mg / d, after an