Of propofol and isoflurane anesthesia in elderly patients with postoperative cognitive function in comparison.docVIP

 PAGE \* MERGEFORMAT 20 Of propofol and isoflurane anesthesia in elderly patients with postoperative cognitive function in comparison [Abstract] Objective To study the application of propofol and isoflurane anesthesia on cognitive function in elderly patients. Methods ASA Ⅰ ~ Ⅱ grade, mood and did not take cerebrovascular disease affect the nervous system function of the drugs in the spirit of Qingdao University Medical College Hospital OK elective non-cardiac surgery 30 patients were randomly divided into two groups, each group 15 cases, respectively, receiving propofol (P group) and isoflurane (I group) anesthesia. Two groups of patients are used intravenous induction of anesthesia with propofol 1.5 ~ 2.0mg/kg, fentanyl 3 ~ 4μ g/kg, vecuronium 0.1mg/kg. Anesthesia maintenance: P Group intravenous infusion of propofol 100 ~ 150μ g / (kg * min), I group inhalation of 1% to 2% isoflurane. Intraoperative monitoring of depth of anesthesia, and adjust the dosage according to BIS values. Postoperative analgesia using patient-controlled intravenous analgesia, method of fentanyl 8μ g/ml, continuous administration of 2ml / h, patient-controlled analgesia administration 0.5ml/15min, analgesic effect using visual analogue scale (VAS) evaluation. Records of preoperative, intubation, 5min, skin incision, extubation 5min, after 1h, 4h, 24h, 48h changes in vital signs of patients, and in patients before and after 1h, 4h, 24h, 48h, using mini-mental state examination ( mini-mental state examination, MMSE) assessed cognitive function of patients. Records of two patients with operation time, blood loss, blood transfusion volume and infusion volume. The results include the testing of 30 patients, all entered the final analysis, half-way non-shedding. General information on two groups of patients, operative time, intraoperative blood transfusion volume and the amount of bleeding, the observation points as well as the vital signs of patient-controlled analgesia visual analogue