P2X purinergic receptors in primary nociceptive role of.docVIP

 PAGE \* MERGEFORMAT 20 P2X purinergic receptors in primary nociceptive role of [Abstract] P2X purinergic receptors (P2X receptors) as ligand-gated cation channels, can be expressed in nociceptive transmission of information with the relevant primary afferent neurons of the cell body, central-side and peripheral side. P2X receptors are involved in peripheral pairs of nociceptive and non-noxious stimuli; in the spinal cord dorsal horn, expressed in the pre-synaptic dorsal root ganglion neurons of P2X receptor activation can be facilitated after the release of glutamate involved in the spinal cord dorsal horn synapses plasticity changes. P2X3 subunit is only expressed in highly selective sensory neurons, the application P2X3 receptor antisense oligonucleotides, gene knockout technology and selective antagonist A317491 studies have shown that ATP and P2X3 receptors in nociceptive modulation and information transmission. [Keywords:] P2X receptors; ATP; receptors, sensory; Neurons, Afferent; spinal cord 0 Introduction P2 purinergic receptor is shared by a variety of cells, a class of membrane receptors can be selectively combined with extracellular ATP, produce different biological effects. According to pharmacological characteristics have been divided into P2X and P2Y receptors, using molecular biology techniques, have seven kinds of P2X receptor subtypes (P2X17) and eight kinds of P2Y receptor subtypes have been cloned (P2Y18)., recent research has confirmed that the nociceptors is rich in the expression of P2X purinergic receptors, especially P2X3 receptor subunits cloning, it is only expressed in highly selective sensory neurons, the P2X purinergic receptors in nociceptive information transmission in the process of gradually increasing the perceived role of researchers attention. 1P2X the general characteristics of purinoceptors P2X purinergic receptors (P2X receptor) is widely distributed in the body in various organizations, including neurons, glial ce