Over 70 years of non-small cell lung cancer drug pemetrexed single first-line treatment of clinical observation.docVIP

 PAGE \* MERGEFORMAT 10 Over 70 years of non-small cell lung cancer drug pemetrexed single first-line treatment of clinical observation [Keywords:] pemetrexed, non-small cell lung cancer, efficacy, median survival Non-small cell lung cancer (NSCLC) accounts for about 80% Feiai, mostly through the occult, the time of diagnosis about 2 / 3 of patients lose the opportunity to surgery, chemotherapy treatment for the main one (1), with the Feiai new and effective drug development the progress of applications, and comprehensive treatment, the treatment improved the survival time is extended (2). to platinum-based combination chemotherapy is the standard first-line treatment of advanced NSCLC treatment. However, for elderly patients, especially older than 70-year-old patients, their functional status and organ function reserve tend to be relatively low, in the course of treatment will cause the platinum chemotherapy-related side effects increased. Therefore, the American Society of Clinical Oncology recommendations for elderly patients with advanced NSCLC patients with high efficiency and low toxicity can be a single agent chemotherapy. Pemetrexed is a multi-target anti-folate drugs, can inhibit folate-dependent enzymes play a Duozhong anti-tumor effect, with high efficiency and low toxicity characteristics (3). For this reason, in recent years, we have some 70 patients with advanced NSCLC over the age of using single-agent pemetrexed first-line treatment, and its efficacy and related factors were observed to provide the basis for clinical treatment. 1 Materials and Methods 1.1 General Information Choose from March 2006 to May 2007 in our hospital patients, were confirmed by pathology or cytology of b ~ NSCLC patients, no major organ dysfunction, blood, liver and kidney function and heart, Coagulation function was normal, with measurable or evaluable tumor lesions, to follow-up. A total of 33 patients were included, 21 males and 12 females, aged 70.1