Pathological epidemiological study of primary liver cancer.docVIP

 PAGE \* MERGEFORMAT 10 Pathological epidemiological study of primary liver cancer Keywords:: Liver Pathology Epidemiology Liver Pathology Research Epidemiology Epidemiology is liver pathology disciplines, its causes and prevention of liver cancer research opened up a new way. On the world is concerned, is the high incidence of liver cancer or low-fat country in the post-mortem incidence of liver cancer in an uptrend 〔〕 1-4. One, causes significant liver tissue surrounding hepatocellular carcinoma around the world, the positive rate of HBsAg varies greatly, Germany 9.52%, Scotland 9.88%, U.S. 35.5%, Thailand 44.4%, Japan 55.2%, Hong Kong 57 .8%, Singapore 74%, China 80.2%, 85.7% of China Taiwan, and India 94%. Although the data sources and the different sensitivity of detection methods, affecting non-cancerous liver tissue of HBsAg detection rate, but at least on one side to understand the world around the liver with HBV-related sexual intensity is not uniform, and even differ greatly. Germany, Scotland, the United States and other Western developed countries show the cause of HBV is more important than 〔 2〕 . P53 gene mutations in hepatocellular carcinoma in the hot spot, that is 249 passwords third base on G: TT: A transversion, resulting in Arg - serine change. This is aflatoxin B1 (AFB1) caused by mutations in animal testing location consistent support of its carcinogenic effects indirectly 〔 5〕 . DENG Zhuo-lin 〔 6〕 AFB1 in Guangxi and other high, medium and low exposure areas HCC samples and found that p53 gene mutation hot spots were 67%, 60% and 10%. Domestic and international studies have shown that, in addition to China and South Africa, the high AFB1 exposure outside the region, in hepatocellular carcinoma (HCC) in the p53 mutation hot spots are rare. P53 mutation hot spots around the world, liver cancer were as follows: Qidong 8 / 16 cases and 13/25 cases, Mozambique, 3 / 10 cases, Chongqing, 6 / 28 cases, the United States 4 / 37 cases, Taiwan