Patients with gastric cancer of plasma soluble vascular endothelial growth factor and its significance test.docVIP

 PAGE \* MERGEFORMAT 3 Patients with gastric cancer of plasma soluble vascular endothelial growth factor and its significance test [Abstract] Objective: Using quantitative ELISA, detection of gastric cancer patients soluble vascular endothelial growth factor (VEGF) levels, and to explore its clinical significance. Methods: quantitative enzyme-linked immunosorbent assay double-antibody sandwich assay 32 cases of gastric cancer patients and 20 normal control subjects, plasma levels of soluble VEGF. Results: Plasma levels of soluble VEGF in patients with gastric cancer were significantly higher than the normal control group, less the degree of differentiation, there is regional lymph node metastasis and distant metastasis of gastric cancer patients were significantly higher than the degree of differentiation is better, no regional lymph node metastasis and distant metastasis of patients. Conclusion: Plasma concentrations of soluble VEGF in predicting invasion and metastasis of gastric cancer may have important clinical significance. [Keywords:] gastric cancer; plasma; vascular endothelial growth factor Vascular tumor growth and metastasis formation is an important condition. Hanah-an made the ‘angiogenic switch hypothesis’ view that the process of tumor angiogenesis by regulating the switch, when the concentration of angiogenic factors increase or decrease the concentration of inhibitory factor, angiogenesis switch in the open state, a large number of new blood vessel formation, tumors were sustainable growth. Tumor-induced angiogenesis is a complex, multi-factor adjustment process, since Folkman in 1973 proposed the concept of tumor angiogenesis factor has been gradually found a variety of vascular endothelial growth factor. Vascular endothelial growth factor (vascular endothelial growth factor, VEGF) is equal to 1989 for the first time by the Farrare calf pituitary follicular cells in vitro from the culture medium of purified extract, is currently the strong