pH-dependent release of new snow pellets and its in vitro release study.doc

 PAGE \* MERGEFORMAT 12 pH-dependent release of new snow pellets and its in vitro release study Study: Warm Song Shu, Yan Li, Kwan Chi, Wang Zhongyan, Mo Feng-Kui [Abstract] Objective To prepare pH-dependent release of new snow pellets was investigated in simulated gastrointestinal pH value of the continuous changes in the environment of the release behavior in vitro. Methods coating pan rolling method, water is adhesive to sucrose Preparation of the blank pill core-type drug-containing pellets were coated with a gastric soluble material (acrylic resin number and two kinds of enteric coated material (acrylic resin No. , number and polyacrylic acid resin emulsion the coating liquid on pellets, pellets of the above three kinds of bags according to the proportion of 1:1:1, pH-dependent release was prepared by micro-pill. and to the index Geniposide release in vitro studies. Results released Determination results show that the release curve showing a gradient of pH-dependent drug release characteristics. Conclusion The preparation of acrylic resin coating materials, pH-dependent release of new snow pellets technology is feasible, reliable, and can achieve better results gradient release . [Keywords:] Pharmacy, pH dependent, in vitro release, Chinese medicine pellets, geniposide New snow by the Gardenia, artificial bezoar, borneol, etc. composed of 24 Chinese herbal medicines for colds, pneumonia, acute respiratory infections of the tonsils and other diseases caused by fever and effective. A new sustained-release pellets of snow flakes is developed on the basis of the new The new formulation can reduce the number of medication, a drug to achieve the purpose of multiple dosing and improve patient compliance. pellets are more decentralized system, a large distribution area in the gastrointestinal tract and bioavailability, will be several different regular release of small units can be combined into multi-unit systems are ideal drug release rate [1,2]. T