Phlegm and collaterals to the United urokinase in acute cerebral infarction in rats in different brain regions of inflammatory factors_0.doc

 PAGE \* MERGEFORMAT 11 Phlegm and collaterals to the United urokinase in acute cerebral infarction in rats in different brain regions of inflammatory factors Study: Zhen Zhou, Yu-Lian Zhang, Guo Jiakui, Wang Zhankui, Liu Shuang, ZHANG Lin-lin [Abstract] Objective To observe the phlegm and collaterals to the United urokinase thrombolysis of acute cerebral infarction in rats in different brain regions of inflammatory factors, to explore the on cerebral ischemia-reperfusion injury in rats. Methods SD rats 136 were randomly divided into 5 groups, namely, the normal group, sham operation group, model group, urokinase group, phlegm and collaterals to the joint UK group, rats were prepared by self-embolic middle cerebral artery occlusion model, were given intragastric and intravenous thrombolytic TCM, Elisa assay phlegm and collaterals to the United urokinase thrombolysis of acute cerebral infarction after 6 h, 72 h, 7 d, 14 d brain tumor necrosis factor - @ (TNF-@) interleukin cell-1β (1L-1β), cell adhesion molecule -1 (ICAM-1) protein expression and other inflammatory factors. The results phlegm and collaterals could inhibit urokinase combined TNF-@, 1L-1β, ICAM-1 protein expression. Conclusion medicine combined thrombolysis can reduce ischemia-reperfusion injury after thrombolysis, which may be associated with inhibition of expression of inflammatory factors. [Keywords:] phlegm and collaterals; thrombolysis; inflammatory factor; ELISA method; ischemia-reperfusion Thrombolytic therapy in ischemic brain tissue can quickly restore blood flow, effective to save the ischemic penumbra function. But can be caused by reperfusion injury and prognosis of the disease have a direct impact. Reperfusion injury raises a number of inflammatory response, including tumor necrosis factor - @ (TNF-@), interleukin cell-1β (1L-1β), cell adhesion molecule -1 (ICAM-1) and other inflammatory factors play an important role. In this study, phlegm Tongluo method combined with uro