Plasma homocysteine and cystatin C in diabetic peripheral neuropathy the role of.doc

 PAGE \* MERGEFORMAT 15 Plasma homocysteine and cystatin C in diabetic peripheral neuropathy the role of Of: Chen Fulian Wang Wenhui Chen Ying Dong Zhenhua Miao Pu [Abstract] Objective To investigate plasma homocysteine (Homocysteine, Hcy and Cystatin C (Cystatin C, CysC and diabetic peripheral neuropathy (DPN relationship. Methods neurological symptoms and EMG will be 103 patients with type 2 Diabetic patients with diabetes were divided into three groups (SDM group, sub-clinical peripheral neuropathy group (SDPN group, peripheral neuropathy group (DPN group), and are located in 30 normal controls (NC) group and impaired glucose regulation (IGR groups. All subjects measuring height, weight, blood pressure, measured plasma concentrations of Hcy and CysC, blood glucose, glycated hemoglobin, lipids, creatinine, fibrinogen, measured by comparing the group differences in indicators, and indicators of Hcy with relevance. Results NC group, IGR group, SDM group, SDPN group, DPN plasma Hcy concentrations were: (6.00 +-1.43mol / L, (7.21 +-1.64mol / L, (8.21 +-2.40mol / L, (12.48 +-4.15mol / L, (13.51 +-5.80mol / L, SDM group, SDPN group, DPN group was higher than NC group, IGR group (P lt;0.05), NC group and the IGR group, DPN group SDPN no significant differences between groups. Pearson correlation analysis showed that plasma Hcy and the negative correlation between nerve conduction velocity test (all P lt;0.05, a positive correlation with reflex latency (all P lt;0.05, and BMI, duration, Cr, CysC, FIB positive correlation (P lt;0.05 or P lt;0.01, control BMI, duration, Cr, FIB after, CysC is still associated with Hcy. Conclusion of plasma Hcy can be used as predictors of DPN, CysC possible interaction with the Hcy and increased DPN. [Keywords:] homocysteine, type 2 diabetes, neuropathy, Cystatin C Diabetic peripheral neuropathy (DPN and vascular foot ulcers occurred, secondary local infection, resulting in diabetic foot, and ultimately lead to amputation a