Plasma homocysteine in patients with coronary heart disease endothelin and circulating endothelial cells and its clinical value.doc

 PAGE \* MERGEFORMAT 9 Plasma homocysteine in patients with coronary heart disease endothelin and circulating endothelial cells and its clinical value OF: open early Autumn Tan Lijuan Yang Aihua Chen Ying Zhang 1 bud [Abstract] Objective coronary heart disease (CHD) patients with plasma homocysteine (Hcy), endothelin (ET), circulating endothelial cells (CEC) levels and atherosclerosis (AS) occurred during the relationship. Methods 56 patients with CHD patients and 46 healthy control group were high performance liquid chromatography and radioimmunoassay determination of plasma levels of Hcy and ET, while the number of plasma in the CEC. Results CHD group of Hcy (20.82 + -6.61 ) mol / L, ET (83.51 + -14.47) ng / L, CEC (11.13 + -6.06) cells/0.9 l, and the control group, Hcy ((9.35 + -2.60) mol / L, ET (48.57 + -15.64) ng / L, CEC (2.61 + -0.89) cells/0.9 l) were significantly different (all P lt;0.001). Hcy and ET, CEC was a positive correlation (r = 0.532, P lt;0.01; r = 0.630, P lt; 0.01), and CHD plasma CEC and ET was positively correlated (r = 0.823, P lt;0.01). Conclusion CEC and ET on the AS occurrence promote the development of joint detection of CHD in the diagnosis and treatment monitoring of important clinical value. [Keywords:] of coronary artery disease; homocysteine; endothelin; circulating endothelial cell [Abstract] ObjectiveTo investigate the role and correlation between changesof the content of homocysteine (Hcy), endothelin (ET) and circulating endothelial cells (CECs) in patients with coronary heart disease (CHD) and atherosclerosis (AS). MethodsHcy, ET and CEC in 56 patients with CHD and 46 normal persons (controls) were detected respectively by high-performance liquid chromatography and radioimmunoassay.ResultsIn CHD patients, the levels of Hcy ((20.82 + -6.61) mol / L), ET ((83.51 + - 14.47) ng / L) and the number of CEC ((11.13 + -6.06) cells/0.9l) were significantly higher than those of controls ((9.35 + -2.60) mol / L, (48.57