Polyaniline - Au composite nano-fibers in the brain neurotransmitters dopamine detection.docVIP

 PAGE \* MERGEFORMAT 25 Polyaniline / Au composite nano-fibers in the brain neurotransmitters dopamine detection 【Abstract】 Objective: To study the polyaniline / Au (PANI / Au) composite nanofibers modified electrode can highly sensitive, high-choice test of brain neurotransmitter dopamine (DA). Methods: Based on the PANI / Au modified electrodes, electrochemical detection of DA in response to current pulse voltammetry analysis of DA and ascorbic acid (AA) co-exist under the circumstances. Results: PANI / Au modified electrode response current of DA available are pure PANI modified electrodes and bare electrodes 1.5 and 2.4 times, and to detect DA and AA, the peak potential difference of up to 260 mV. Conclusion: PANI / Au composite nanofibers modified electrode can improve the detection sensitivity and selectivity of DA. Keywords: composite nano-fibrous PANI gold nano-particles of ascorbic acid of dopamine electrochemical Dopamine (DA) in the human central nervous system is a very important information to pass the material, its content changes can lead to a number of important diseases such as Parkinson’s disease and schizophrenia. Therefore, its determination method study to explore the physiological mechanisms and diagnosis of related diseases of great significance [1]. Determination of DA is currently the principal methods of spectrophotometry, chemiluminescence method, high-performance liquid chromatography and electrochemical method. Electrochemical preparation of which method is simple, easy to operate, etc., and the adoption of the modified electrode can be increased DA and mass transfer rates, increase the sensitivity of determination [2  3]. Under normal circumstances, however, DA is and ascorbic acid (AA) co-exist in the brain and body fluids, in the solid electrode the oxidation potential of DA and AA and easily produce similar interference, and therefore achieved high sensitivity of the DA signals and interference with anti-AA