Polysaccharide anti-tumor mechanism of biological research.doc

 PAGE \* MERGEFORMAT 7 Polysaccharide anti-tumor mechanism of biological research [Keywords:] biological mechanism of anti-tumor effect of polysaccharide Progress Polysaccharide (polysaccharide) is a more than 20 monosaccharides connected by glycosidic bond formation of aldehyde or ketone containing multiple hydroxyl polymer and its derivatives, widely distributed in animals, plants and micro-organisms in the cell wall. It constitutes the basic material of life, one of the four. Polysaccharide because of its bio-synthesis reaction as well as in cell-cell recognition, fertilization, embryo formation, nerve cell development, hormone activation, cell proliferation, viral and bacterial infection, tumor cell metastasis, and many other basic life processes of the important role of the broad - biological functions. Studies have shown that polysaccharides with immunomodulatory, anti-tumor, anti-inflammatory, anti-virus, anti-oxidation, anti-radiation, lowering blood sugar, blood lipid, nourish the liver and many other functions, including anti-tumor effect of polysaccharide and paid close attention to the role of immune regulating activity , the author of the recent anti-tumor mechanism of polysaccharide of research are reviewed. 1 on the direct inhibition of tumor Wei-Fa Zheng et al [1] to S180 sarcoma tumor model for testing Aphanothece halophytica exopolysaccharide (EPAH) on the tumor growth inhibitory activity; MTT assay EPAH on S180 sarcoma cells, Smcc7721 hepatoma cells and HeLa cells in vitro inhibitory activity. The study found, EPAH significant anti-tumor activity, and can directly act on tumor cells, inhibit tumor growth. Yan Bo-Min et al [2] study found that spirulina platensis on cultured human hepatoma cells HepG  2 has a significant inhibition of proliferation, and different concentrations of Spirulina polysaccharide could inhibit liver cancer cells, insulin-like growth factor 2 (IGF  2) mRNA expression, suggesting that Spirulina polysaccharides i