Precursors of lipid body to the entire lung surfactant lung lavage rabbit model of the therapeutic effect of respiratory distress.doc

 PAGE \* MERGEFORMAT 11 Precursors of lipid body to the entire lung surfactant lung lavage rabbit model of the therapeutic effect of respiratory distress 【Abstract】 Objective: To observe the size of lipid precursors lung surfactant (PPPS) for the whole lung lavage rabbit model of the therapeutic effect of respiratory distress. Methods: PPPS After hydration by tracheal instillation treatment of a whole lung lavage model in adult rabbit model of respiratory distress were observed in rabbits of vital signs, blood gases, dynamic lung compliance and other indicators of change. Results: The model of the whole lung lavage in rabbits after blood gas pH, PaO2 decreased sharply, PaCO2 mild increase in heart rate and respiratory rate increased significantly slowed down, SBP and DBP were significantly decreased; bronchoalveolar lavage fluid were significantly decreased in the PS; pathology Check prompted pulmonary hemorrhage, atelectasis, alveolar atrophy, hyaline membrane formation of lesions, consistent with severe respiratory failure in type Ⅰ clinical diagnostic criteria. PPPS by tracheal instillation, the rabbits can make RDS the indicators (pH, PaO2, PaCO2, HR, BR, SBP, DBP) significantly improved lung pathological change also reduced significantly. Statistical analysis The results suggest that the treatment group and the control group pH (F = 4.572, P = 0.046), PaO2 (F = 557.586, P = 0.000), PaCO2 (F = 96.798, P = 0.000), TV (F = 117.851, P = 0.000), Cydn (F = 276.996, P = 0.000), HR (F = 34.975, P = 0.000), BR (F = 28.167, P = 0.000), SBP (F = 124.751, P = 0.000) and DBP (F = 108.672, P = 0.000) were statistically significant difference; in the treatment group, at each time point of the pH, PaO2, PaCO2, TV, Cydn, HR, BR, SBP and DBP differences were statistically significant compared . Conclusion: PPPS on experimental PS deficiency and lung injury caused by respiratory distress significant therapeutic effect. Keywords: pulmonary surfactant; prolipo