Pregnancy-induced hypertension and endothelial cells in vitro.docVIP

 PAGE \* MERGEFORMAT 8 Pregnancy-induced hypertension and endothelial cells in vitro Keywords:: pregnancy-induced hypertension pre-eclampsia endothelial cell A few years ago, it was suggested that vascular endothelial cells is the placenta of women with pregnancy induced hypertension produced by some of the substances released into the blood circulation of the primary target body. This review summarizes the foreign scholars in recent years, research in this area received a different conclusion on the causes of their conduct related discussions. Pregnancy-induced hypertension women’s blood on the role of endothelial cells in vitro First, consistent with the in vivo evidence of endothelial cell injury Platelet-derived growth factor (PDGF) has a strong vasoconstriction, Taylar confirmed that pre-eclampsia and other women’s prenatal and postpartum sera sera compared to that arouse the endothelial cells in vitro the mRNA expression of PDGF increased, while the normal pregnant women no such difference in serum before and after childbirth, so that the aura epileptic women’s serum contains a factor can cause the release of vascular endothelial cell contraction factor [1]. Lorentzen, etc. found in the serum of women with preeclampsia can pre-cultured endothelial cells, PGI (PGI2) release to reduce the [2]. Taylar in vitro cultured human umbilical vein endothelial cells by adding pre-eclampsia serum of women in antenatal, postnatal serum and normal serum of pregnant women, prenatal women, discovered that adding a pre-eclampsia serum endothelial cells as compared with the latter two can produce More fibronectin (FN) [3]. Haller’s research shows that pre-eclampsia the serum of pregnant women make in vitro cultured endothelial cells, intracellular adhesion molecule (ICAM) to increase [4]. Second, endothelial cell injury in vivo evidence to the contrary Although in vitro cell culture experiments have been some in vivo endothelial cell damage in patients with pregnancy