Preparation and delivery of ibuprofen analysis of the nature.doc

 PAGE \* MERGEFORMAT 10 Preparation and delivery of ibuprofen analysis of the nature Of: Nie Chuanping Caohong Zhao Guowei Ying [Abstract] orthogonal design to pass the body ibuprofen prescription ibuprofen prepared to pass the body size distribution (122.3 + -31.9) nm, and water-methanol (20:80,0.1% TFA) as the mobile phase, HPLC measured the average encapsulation efficiency was 48.92%. the initial stability study showed that at low temperature (4 ℃) storage of 7 d, the average particle size and distribution of products, small changes, drug leakage less than 3%, with the more stable for ibuprofen drug delivery technology offers a new basis. [Keywords:] ibuprofen; transfer body; encapsulation efficiency; stability; leakage Transfer body (transfersomes, TF) is a lipid aggregate, the main components of phospholipids and surfactant (eg sodium cholate, sodium deoxycholate, etc.) [1]. Diameter of tens to hundreds of nanometers, the appearance of colloidal solution, also known as flexible nano-liposomes (flexible nano liposomes, FNL) [2]. TF is derived from the liposomal formulation improved, embedded in the vesicle membrane is highly surface-active agent to deformation, and efficiently penetrate several times smaller than the channel itself, it can be used as a variety of macromolecules, water-soluble or fat-soluble drug carriers. ibuprofen (1) a short biological half-life, needs frequent maintenance treatment of drug concentration, may increase gastrointestinal Road side effects [3] and the liver and kidney damage effect [4]. to alleviate an adverse reaction at home and abroad in recent years developed a variety of new agents and formulations of new technologies, such as orally disintegrating tablets, ophthalmic nano-suspension formulations, transdermal drug delivery micro-gel carrier and lipid nanocapsules. This test combined with a physical and chemical properties, the use of the new TF technology envelope 1, in order to relieve one of the adverse rea