Preparation of cardiac deficiency model.doc

 PAGE \* MERGEFORMAT 8 Preparation of cardiac deficiency model OF: TRADITIONAL YAO Xia Yu-Tang Ye Fu Gong Wenbo [Abstract] Objective: To study the rat animal model of heart deficiency. Methods: Adult inbred Wistar rats were 26, were randomly divided into control group and model group swimming, swimmers swim twice a day with Law, forced swimming to exhaustion in rats, the 18th day of experiment, on the basis of the daily fed swimming propranolol solution 2.4mg/100g, 4 consecutive days, experimental modeling the end of the first 22 days. Results: The swimmers In the modeling, gradual weight loss after 3 days to 21 days of the experiment, body weight was significantly lower than the control group (P lt;0.01), maximum ventricular pressure, mean left ventricular peak pressure, heart rate decreased, compared with the control group were statistically different significance (P lt;0.05 or P lt;0.01). Conclusion: physical decline swimming rats, cardiac function, and meet the clinical characteristics of heart qi, heart qi deficiency rat model was successfully. [Keywords:] rats, heart qi deficiency, animal models Abstract Objective: To reseach the method for preparing rat model of deficiency of heart-energy. Methods: 26 adult inbreeding line Wistar rats were randomly divided into the control group and the model group (males and females on halves). Every animal in the model group was forced to swim with slimming within 22 days. From 18th day propanolol was given, for 4 days. On the 21st day haemodynamics was measured in the model group and the control group. Results: The rats’ weight in the swimming model group started to decrease from the 3rd day after model-preparing and there was a loss of weight on the 21st day. Such indexes in the experiment group as intraventricular pressure max, + dp / Pdtmax mean, HR were significantly lower than those in the control group ( P lt;0.05). Conclusion: Rats’ physical strength in the model group decline and their heart functi