Preparation of dispersible tablets bonus Technology and Quality Control.doc

 PAGE \* MERGEFORMAT 9 Preparation of dispersible tablets bonus Technology and Quality Control Authors: Yang Xin-Gang, Duan Guo-Hao, Zhao Yi Xue [Abstract] Objective To investigate the bonuses dispersible tablets of the preparation process and the optimal prescription. Ways to spread the evenness index for the study on the bonus screen tablet prescription. Results According to the optimized prescription tablet prepared by the indicators bonus eligible, dissolution tests showed that the dissolution of this product as compared with ordinary tablets. Conclusion The method developed bonus tablet prescription reasonable and technology is feasible, reflect the characteristics of dispersible tablets. [Keywords:] bonus dispersible tablets; dispersion uniformity; dissolution Dispersible tablet is a new solid dosage forms, with the rapid disintegration, dissolution uniform and high bioavailability, either orally, can also be made of a small amount of water after the dose of suspension can be avoided or a greater volume of the film need to the elderly take more films and swallowing difficulties in patients with trouble. Bonus dispersible tablets from the national drug standards have been closed out in WS  10179 (ZD  0179) 2002, with the heat dampness, blood stasis and analgesic efficacy; for more than the amount taken off the color yellow quality thick, abdominal pain, etc. disease, clinical effect is significant. Preparation of dispersible tablets have important therapeutic bonus significance and broad market prospects, so we have to diversify evenness index for the study, preparation of dispersible tablets of the bonuses have been studied, and bonuses dispersible tablets in vitro dissolution of the original tablet was comparison. An apparatus and materials 1.1 Instrument GFFJ-8 micro-grinder Group (Jiangyin treasures Industrial Corporation); WK  60-type particle machine (Jiangsu Taixing Pharmaceutical Machinery Plant); ZP-7A-type rotary tablet machine (Shang