Preparation of liposome nanoparticles slips and Stability.docVIP

 PAGE \* MERGEFORMAT 9 Preparation of liposome nanoparticles slips and Stability On: Zheng Mingbin, Ping Gong Yang Xuemei Li Shangde Wuxi Ren Mei Jun [Abstract] Objective To prepare the package containing slips of liposomes and to study the stability of nano-particles. Methods rotary film evaporation method using nano-kava preparations, and its shape and size were characterized to study the stability of nanoparticles . the result slips liposome nanoparticles average diameter (99.7 + -7.6) nm, polydispersity index was 0.321 + -0.011, Zeta potential of (-33.9 + -2.3) mV, the encapsulation efficiency was (83.32 + - 0.34)%; nano solution placed at 4 for 60d, the appearance of nanoparticles, particle size and entrapment efficiency did not change significantly the difference was not statistically significant (Pgt; 0.05). Conclusion slips package liposome nanoparticles higher closure rate and particle size distribution, good stability, for the development of new dosage forms kava provide an experimental basis. [Keywords:] slip; liposomes; stability Abstract: Objective To prepare the kava loaded lipid nanoparticles from Piper methysticum and study their stability.Methods Kava loaded lipid nanoparticles were prepared by rotary film evaporation method, and their appearance, size and stability were observed.Results Mean size, polydispersity index, Zeta potential , and entrapment efficiency of kava loaded lipid nanoparticles were 99.7 nm, 0.321, -33.9 mV, and 83.32%, respectively. Their appearance, size and entrapment efficiency showed no obvious changes after storage at 4 for 60 days. Conclusion The kava loaded lipid nanoparticles have high entrapment efficiency, uniform particle size and good stability. The present study provides the experiment evidence for the development of novel dosage form of kava. Keywords:: Piper methysticum (kava); lipid; stability Kava plant extracts rich in oil from the South Pacific island kava pepper plants (Piper methysticum)