Primary drug resistance in refractory acute myeloid leukemia in 1 case.doc

 PAGE \* MERGEFORMAT 5 Primary drug resistance in refractory acute myeloid leukemia in 1 case [Keywords:] primary drug resistance in refractory acute myeloid leukemia A case report Male patient, 20 years old, the main reason: “chills, fever, cough 2 weeks” in March 2, 2006 admission. 1 week before admission, hospital out-patient treatment has been diagnosed as: (1) acute myeloid leukemia (M2 @), (2) acute bronchitis. past history, no special family. admission examination: body temperature 37.0 ℃, pulse 82 beats / min, breathing 20 times / min, blood pressure 100/58mmHg, Shen Qing, normal development, nutrition medium , body skin, mucosa stained, petechia, ecchymosis, swelling of superficial lymph nodes are not touched. pharyngeal congestion (+), and bilateral tonsil enlargement of grade Ⅰ, smooth surface, no pus points. neck soft, no heart and lung auscultation abnormalities, abdominal soft, whole abdomen without tenderness, rebound tenderness, palpable spleen and ribs 2cm, mass medium, no tenderness, shifting dullness (), bowel sounds normal. Laboratory examination: urine normal, liver function, biochemistry, the three basic normal blood clotting, C-reactive protein 24mg / L, blood: WBC14.5 × 109 / L, GRA42%, LYM40%, MID18%, RBC2.77 × 1012 / L, HCT25.5%, HGB90g / L, PLT90 × 109 / L, ECG, chest anteroposterior film, head CT were normal. Abdominal B-Tip: splenomegaly, splenic lesions within the substantive nature to be determined. bone marrow: proliferation of granulocyte extreme active 84%, 41% of the original cells, early action, 28% granulocytes, still see a few in the fine grain, late immature and mature myeloid grain, the final diagnosis of acute myelogenous leukemia. admission to the standards of DA has Option 2 Option 1 HA treatment and course of treatment, the bone marrow after treatment review are as follows: 30.5% of the original, early grain 3%, 79% of the original, early grain 1.5%, 60% of the original, early 35 tablets %. patients after che