Proanthocyanidins on experimental thrombosis.doc

 PAGE \* MERGEFORMAT 27 Proanthocyanidins on experimental thrombosis Author: Jiang Xin, Zhao Liang, China, Zhang Hailong, Zhang, Wang Hua-zhou Abstract This study aims to explore the procyanidins (PC) of anti-thrombosis and its mechanism. Anesthesia animals, and then to the carotid artery to impose 20% ferric chloride solution of partial 20 minutes, to cause rat carotid artery thrombosis model. Experiment in 6 groups: sham thrombosis (control) group, thrombosis model group, aspirin [10 mg / (kg * d)] Group, PC 100 mg / (kg * d) Group, PC 200 mg / (kg * d) Unit and the PC 400 mg / (kg * d) group. False thrombosis (control) group and the thrombosis model group fed with normal saline, the other groups were used aspirin and PC low, medium and high doses of three different suspension given orally 2 times a day for 4 weeks. Observed in each group of drugs on experimental thrombosis in rat plasma thromboxane (TXB2) and 6   keto prostaglandin F1α (6  Keto  PGF1α) and platelet P  selectin (GMP  140)) content in . The results showed that: ① the control group compared with sham-thrombosis, thrombosis model plasma TXB2 and platelet P  selectin (GMP  140) were significantly increased, plasma 6  Keto  PGF1α decreased significantly, the difference very significant (P lt;0.01) ; ② with thrombosis model group, 3 PC group and the aspirin group plasma TXB2 and platelet P  selectin (GMP  140) were significantly lower, the difference very significant (P lt;0.01), plasma 6  Keto  PGF1α were significantly higher (P lt;0.01); ③ with the aspirin group, three PC plasma TXB2 and platelet P  selectin (GMP  140) levels were reduced to varying degrees, while plasma 6  Keto  PGF1α content increased, particularly among the PC 400 mg / (kg * d) group of the most significant (P lt;0.01). Conclusion: PC with a significant antithrombotic effects, and antithrombotic mechanisms and inhibition of platelet activation, aggregation and protection of vascular endothelial cel