Probucol on carotid atherosclerosis Clinical study.doc

 PAGE \* MERGEFORMAT 12 Probucol on carotid atherosclerosis Clinical study Of: Zhang Baohong Liu Yun Wang Guangyao change [Abstract] Objective: To investigate the probucol on atherosclerosis of carotid artery plaque. Methods: 50 patients with coronary heart disease determined by color Doppler before 12 weeks of oral administration of probucol, neck atherosclerotic plaques block size, while testing drugs before and after serum total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol. Results: After 12 weeks, significantly reduced carotid plaque. probucol no significant effect on triglycerides, but serum total cholesterol and LDL cholesterol were significantly reduced. CONCLUSION: Probucol may stabilize or reduce carotid artery plaque, prevention and treatment of coronary heart disease has important clinical significance. Abstract Objective: To explore the effect of Probucol on carotid atherosclerosis plaque. Methods: Carotid atherosclerosis plaque were measured by color Dopplar in 50 patients with coronary heart disease 12 weeks before and after administration of Probucol (orally). Meanwhile, serum total cholesterol (TC ), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were determined as well by routine. Results: At the end of 12 weeks, the carotid atherosclerosis plaque decreased markedly. Probucol did not change serum levl of TG, but the serum levels of TC and LDL-C were significantly lowered. Conclusion: Probucol may stabilize or decrease carotid atherosclerosis plaque, which is of great clinical significance for prevention and treatment of coronary heart disease. Keywords: Probucol; Atherosclerosis; Plaque Coronary heart disease is the most common cardiovascular diseases. Now known to influence the development of coronary heart disease and many factors, however, hyperlipidemia, especially hypercholesterolemia, is caused by athero