Procyanidins on focal cerebral ischemia in type 2 diabetes hippocampus of nNOS.docVIP

 PAGE \* MERGEFORMAT 10 Procyanidins on focal cerebral ischemia in type 2 diabetes hippocampus of nNOS [Abstract] Objective proanthocyanidins (procyanidin, PC on focal cerebral ischemia in type 2 diabetes in rat brain neuronal nitric oxide synthase (nNOS expression. Methods 66 rats were randomly divided into sham group, type 2 diabetes group and the PC ischemia alone group (100 mg / kg, respectively 3,6,12,24,48 h after application of nNOS immunohistochemistry semi-quantitative analysis of the line. Results hippocampal area has a large number of nNOS immunoreactive cells, beginning 3 h after ischemia the expression, 6 h reached a peak, 12 h and then decreases, at the same time, the model group was significantly higher than the sham group (P lt;0.01), PC group than in model group was significantly lower (P lt;0.01), with no significant difference between sham group (Pgt; 0.05). Conclusion The PC has a lower type 2 diabetes, cerebral ischemia and focal cerebral ischemia in rats nNOS activity in hippocampus . [Keywords:] diabetes, ischemic neuronal procyanidins nitric oxide synthase Diabetes is a major cerebrovascular disease risk factors, high blood sugar can cause or aggravate ischemic brain damage. Although there are several drugs currently used clinically, but the effects are not ideal. Ischemic brain damage is caused by various pathogenic factors participation, and jointly promote the results of the oxygen free radical damage is the most important and positive factor. proanthocyanidins (procyanidin, PC is a good scavenger of oxygen free radicals and lipid peroxidation inhibitor [1], on serum and brain tissue lipid peroxide formation inhibited. We intend from neuronal nitric oxide synthase (nNOS PC in terms of type 2 diabetes, lack of focal cerebral The neuroprotective mechanism of the blood, provide a theoretical basis for its clinical application. 1 Materials and methods 1.1 The selection of experimental animals 66 healthy male SD rats, weighi