Progress in pancreatic regeneration factor.docVIP

 PAGE \* MERGEFORMAT 17 Progress in pancreatic regeneration factor [Keywords:] pancreas regeneration associated factors, research progress Inside and outside the pancreas is an important mixed gland secretion, experiments can be found in the pancreas regeneration after injury occurred. Pancreatic regeneration involves complex cell - cell interactions between the various factors, these factors include the role of signal transduction from the ligand, by body, extracellular matrix and adhesion molecules, this process accompanied by a series of related gene expression and regulation. This paper reviews recent studies related factors pancreatic regeneration progress. A growth factor and related peptide Epidermal growth factor (Epidermal Growth Factor, EGF) is a small peptide of 53 amino acid residues, is a multifunctional growth factor, both in vivo and in vitro on a variety of tissue cells have a strong mitogenic effect. Suarez -Pinzon et al [1] study showed that NOD mice, the combination of EGF and gastrin can increase the number of islet cells and reverse hyperglycemia in mice. Miettinen et al [2] found that EGF down by the islet cells body signaling pathway, weakening the newborn mice pancreatic @ cell growth, leading to the development of diabetic mice. In ischemia-reperfusion-induced acute pancreatitis, giving exogenous EGF, reduces inflammation of the pancreas, limiting the extent of pancreatitis, promoting repair and regeneration of pancreas. These suggest EGF might be involved in islet regeneration and repair of pancreatitis. Fibroblast growth factor -2 (fibroblast growth factor-2, FGF-2) ((basic FGF containing 155 amino acids is mitogenic cationic peptides. Strict and strong [3] used rats with acute edematous pancreatitis model was the early administration of exogenous FGF-2 on acute edematous pancreatitis in rats, they found that early treatment of FGF-2 can improve the bombesin-induced acute edematous pancreatitis induced histologica