Progress in pregnancy-induced hypertension cause.docVIP

 PAGE \* MERGEFORMAT 16 Progress in pregnancy-induced hypertension cause Keywords:: 1. Pregnancy Complications Cardiovascular / etiology 2. Pregnancy Complications Cardiovascular / immunology 3. Hypertension / etiology four endothelial vascular / pathology 5. 1 NO Pregnancy induced hypertension (PIH) is a multi-occurred after 20 weeks of gestation with high blood pressure, proteinuria, edema, characterized by a syndrome of multiple organ dysfunction. First reported more than 100 years ago has still a serious threat to the safety and health of mother and child. With regard to its causes and pathological changes of many theories, but so far inconclusive. In recent years, studies have shown that, PIH incidence and immune imbalance, vascular endothelial cell dysfunction, intracellular Ca2 concentration, as well as nitric oxide (NO) and other factors related to this article on the progress of their research are summarized below. 1. And immune imbalance in the occurrence of pregnancy-induced hypertension Under normal pregnancy circumstances, the fetus from rejection of the response (such as anti-T-cell activity, complement fixation antibodies, macrophages and NK cell activity, etc.) decreased, while the protective effect of fetal response enhancement (such as blocking antibodies generate increased). Studies suggest that the incidence of pregnancy-induced hypertension and immune imbalance related to changes in the immune system and normal pregnancy the contrary, the showed the fetus rejection was increased and decreased the response protective effect of the sky. Study found that peripheral blood lymphocytes in patients with PIH on phytohemagglutinin (PHA) to stimulate the stepmother cell lymphocyte reaction and their spouses, one-way mixed lymphocyte culture responses are weakened, that the PIH thus an immune dysfunction disease. Another PIH in patients with enhanced macrophage function has been activated and released cytokines, may be involved in PIH vascular en