Prolonged exercise in normal rat body temperature and fever response to LPS and IL-6 affect the relationship between the.doc

 PAGE \* MERGEFORMAT 22 Prolonged exercise in normal rat body temperature and fever response to LPS and IL-6 affect the relationship between the Abstract of a long period of exercise training on body temperature in normal rats and bacteria ester polysaccharide (LPS) causes fever reaction and interleukin -6 (IL-6) relationship. Methods Using wireless telemetry measurement of body temperature and activity in rats. After 8 weeks training in the use of wheel to observe prolonged exercise training on body temperature in normal rats, and LPS (50μg/kg) causes fever reaction. Using double-antibody sandwich ELISA, plasma IL-6. Results ① voluntary wheel exercise training in rats after 8 weeks, day and night temperature were significantly improved. During the day, exercise group rats than in the control group increased an average body temperature of 0.4 ℃; at night, exercise group than in the control group increased 0.5 ℃. ② prolonged exercise training can significantly improve the animals to the LPS fever response to LPS in the daytime that is able to enhance the sports training group and control group animals, body temperature, but the exercise training group was significantly higher fever response. ③ In the daytime, sports and the activities of the control group is almost the same; but at night, slightly higher exercise group’s activities. ④ prolonged exercise training can significantly improve the plasma IL-6 levels, particularly to improve the more obvious after LPS. Conclusion experiments show that prolonged exercise training can significantly improve the rat’s normal body temperature and fever response to LPS, its role and increase in plasma IL-6 is closely related. Keywords: body temperature of interleukin -6 exercise training fever Abstract: Objective To determine the effect of long-term exercise training on normal body temperature and lipopolysaccharide (LPS)-induced febrile responses in the rat and the relationship with interleukin-6 (IL