Protein kinase C and peripheral nerve regeneration.docVIP

Protein kinase C and peripheral nerve regeneration Keywords: protein kinase C in peripheral nerve regeneration With the cell biology and molecular biology of the rapid development of peripheral neuropathy (Peripheral nerve, PN) regeneration of the research focus from the 80’s use of microsurgical techniques to enhance nerve repair operations gradually shifted to the fine regulation of nerve regeneration of the local or the whole of the biological factors. Among them, nerve cell regeneration adjustment mechanism has aroused great concern. Intracellular bio-information transmission system is between a variety of extracellular factors and cells to produce a bridge between the regeneration effect, involves a number of important aspects, protein kinase C (Protein kinase C, PKC) is one of them, it is by influencing the a variety of protein substrate phosphorylation, involved in a range of biological phenomena related processes, such as participation in cell signaling, controlling cell proliferation and differentiation, regulating gene expression, changes in cell morphology involved in neurotransmitter release, etc. [1]. In recent years, many scholars of PKC in the PN’s role in the regeneration of a meaningful discussion. 1 PKC in peripheral nerve of the normal distribution PKC is a Nishizuka equal first discovered in 1977, after nearly 20 years of research, so far identified at least 12 subtypes, according to its structure and co-factor of the different PKC usually divided into three major categories, namely, the typical PKCs (α , β Ⅰ , β Ⅱ , γ ), new PKCs (δ , ε , η , θ , μ ) and atypical PKCs (ζ , λ , ι ) [1,2]. PKC isoforms in addition to the structure of these there are differences, at the cellular and subcellular distribution, substrate specificity, the sensitivity of the activation signal as well as reduced susceptibility, etc. are different, so they have their own special functions. Miki [3] used immunohistochemistry to compare the rat cervical spinal cord