Proteomics study of bone and joint diseases in the application of.docVIP

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2017-05-05 发布于浙江
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Proteomics study of bone and joint diseases in the application of.doc

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Proteomics study of bone and joint diseases in the application of

Proteomics study of bone and joint diseases in the application of [Keywords:] protein As the activity of the protein molecules in cells, their expression levels change with disease, drug or toxin directly. Proteomics theory and technology development and improvement of people of proteins from tissue or cells to understand disease as the overall level of possible. This technology will be the detection of disease markers, identification and evaluation of drug target proteins and other useful tools. 1 The concept of proteomics and Significance Proteome (Proteome) and Proteomics (Proteomics) The proposal has been 10 years or so. Proteome word, derived from protein (protein) and genomic (genome) hybrid of two words, means “a genes expressed by the full set of proteins “, which includes a biological cell or even a whole expressed protein. proteome is a dynamic concept, in the same body in different tissues and cells are not the same, the difference in the same body developmental stage, different physiological conditions, even under different external environment is not the same. a variety of complex life activities are specific proteins at different time and space groups of different combinations of results. Proteomics is the large-scale, systematic basis in the overall level of proteome research of a new subject [1], including the dynamic changes of intracellular components of the protein expression levels and posttranslational modification state of proteins between the role and links. proteomics can be divided into expression proteomics and comparative proteomics [2]. The former by comparing the analysis of different physiological and pathological conditions of cells, tissues or body fluids similarities and differences in protein expression screening with clinical signs of many The key significance of the protein molecule. which purpose is to establish the protein expression profile and the modified spectrum of the database, cellular localization map, t