Psoriasis and vascular endothelial growth factor.docVIP

Psoriasis and vascular endothelial growth factor Abstract: Psoriasis is an inflammatory disease, angiogenesis is a feature of the pathological changes of psoriasis. As an indispensable condition for the occurrence and development of psoriasis, angiogenesis-related factors in the pathogenesis of psoriasis and more attention. Psoriasis is a number of angiogenesis in the present study, the more hot spots of angiogenesis-related factors: vascular endothelial growth factor, hepatocyte growth factor, thymidine phosphorylase, platelet-reactive protein and other research advances are reviewed. Psoriasis is a common recurrent, inflammatory skin disease. To keratinocytes (KC) hyperplasia, inflammatory cell infiltration, neovascularization, the three elements of its pathology. The current study shows that: Psoriatic Lesions of the dermal papilla layer of capillary expansion and tortuous, and permeability, vascular volume increased, and that this change occurred mainly in post-capillary venules [1]. Psoriasis in the first pathological changes occurred in the distribution and formation of vascular changes [1,2]. In psoriatic skin lesions are usually of the non-patient to see the abnormal expansion of blood vessels [2]. Recurrence of the lesions of psoriasis within the dermal papilla and the endothelial cells over-expression. And the skin angiogenesis in patients with psoriasis related to changes only with the skin, but has nothing to do with the leather [3]. Microvascular skin blood organizations and the cycle of material exchange places. Therefore, the study of angiogenesis in psoriasis will help reveal the pathogenesis of psoriasis, and to guide clinical treatment. Psoriasis is currently on angiogenesis, especially angiogenesis related factors, as well as anti-angiogenesis drug treatment study of psoriasis and more attention. Angiopoietin-induced angiogenesis, the process of material can be broken down roughly into the following steps: ① endothelial cell activation;