Psoriasis genetics and genetic research.docVIP

Psoriasis genetics and genetic research Abstract: In recent years, psoriasis genetics and genetic research has made great progress, found that certain HLA antigens and HLA haplotypes closely with psoriasis, and with age-related incidence of psoriasis. Through ‘fixed-point cloning’ technology and genome-wide scan has identified on chromosome lq, 4q, 16q, 17q, 6q21, and 2,8,20 there associated with psoriasis susceptibility gene mutations. Psoriasis is a characteristic clinical lesions there, and inflammation, excessive proliferation of skin disease. Whites in North America and Northern Europe, about 2% of people get sick, but in Japan and North America, South America, relatively few blacks in the patients [1]. Through a large number of people, family and twin studies show that genetic factors constitute an important factor in psoriasis susceptibility. On in recent years in genetics and genetic aspects of psoriasis research are reviewed. 1, HLA associated with psoriasis The genetic characteristics of psoriasis, as well as epidemiological data to enable people to design research programs to determine whether the MHC of the HLA loci with psoriasis to genetic factors. Nair et al [2] In 12.5cM genome-wide scans, suggesting linkage of psoriasis with HLA region (Zmax = 3.52, P ≤ 0.01), exist in the HLA locus of psoriasis susceptibility loci. Jenisch, etc. [3] Application of transmission / disequilibrium test (TDT) and parametric linkage analysis methods and found that psoriasis and HLA-C,-B,-DR,-DQ side locks, of which HLA-B,-C the most significant. In 1993, Schmitt et al [4] for the first time at the DNA level to detect alleles and HLA Ⅱ Ⅰ type psoriasis with a clear link. They used DNA nucleotide sequence-specific oligonucleotide probe pairs of 47 cases of type Ⅰ (onset before the age of 40, there is positive family history) and 17 cases of type Ⅱ (onset after the age of 40 with no family history) psoriasis patients with a genetic sub-type The results s