QBC939 hydroxycamptothecin on human cholangiocarcinoma xenografts in nude PS2 COX2 of.docVIP

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2017-05-05 发布于浙江
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QBC939 hydroxycamptothecin on human cholangiocarcinoma xenografts in nude PS2 COX2 of.doc

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QBC939 hydroxycamptothecin on human cholangiocarcinoma xenografts in nude PS2 COX2 of

QBC939 hydroxycamptothecin on human cholangiocarcinoma xenografts in nude PS2 COX2 of [ABSTRACT] Objective QBC939 hydroxycamptothecin on human cholangiocarcinoma xenografts in nude mice breast cancer-related peptide (PS2), cyclooxygenase 2 (COX 2) the impact analysis of PS2, COX 2 with tumor occurrence and development of the relationship between . Methods QBC939 human cholangiocarcinoma cell lines transplanted into nude mice model, 30 mice were randomly divided into control group, HCPT HCPT low dose group and high dose group, the growth of implanted tumor, RT PCR Detection of intratumoral PS2, COX 2mRNA expression. The results compared with the control group, HCPT low and high dose group transplanted tumor can make the PS2 mRNA expression increased, COX 2 mRNA expression decreased, and the slow tumor growth with the control group the difference was statistically significant (P lt;0.01). Conclusion hydroxycamptothecin reduces the expression of tumor COX 2mRNA, increased expression of transplanted tumor of the PS2 mRNA, and cause people to slow down the bile duct carcinoma in nude mice . [Keywords:] cholangiocarcinoma cells in nude mice transplanted QBC939 PS2, COX 2 ABSTRACT: Objective To investigate the effect of hydroxycam ptothecine on PS2 and COX 2 in nude mice by human bile duct carcinoma QBC939 cells in order to analyze the correlation between PS2 and COX 2 expressions and the development of the tumor. Methods After the model of the transplanted tumor of subcutaneous tissues located the nude mice was constructed by human bile duct carcinoma QBC939 cells, 30 nude mice were randomly divided into 3 groups, namely, control group, hydroxycamptothecine low dose group and high dose group. The growth of the transplanted tumor was observed and immunohistochemical staining combined with image analysis was used to determine the expression of PS2 and COX 2 in the tumor tissues. Results Compared with that of the control group, the content of PS2 in the tumor tissue