Qi Yin meridians of Chinese medicine Xiaozheng kidney of diabetic rats protective effect.docVIP

 PAGE \* MERGEFORMAT 14 Qi Yin meridians of Chinese medicine Xiaozheng kidney of diabetic rats protective effect Of: Zhao Wen Hung, Chen Zhiqiang, Sun Yufeng, Jiang-Hua Zhang, Yue-Hua Wang, commercial Yaru [Abstract] Objective Yiqiyangyin Xiaozheng Tongluo Herbs on oxidative stress in kidneys of diabetic rats were studied to analyze the mechanism of diabetic nephropathy. Methods SD rats were randomly divided into 6 groups: nephrectomy group, model group, irbesartan group, Chinese medicine low, medium and high dose group, the corresponding dose by gavage of each group. in the first 6 weeks, the rats were detected 24 h urine protein (U Pro) the amount of the level of renal function; renal cortical malondialdehyde (MDA), superoxide dismutase (SOD) activity. The results irbesartan, medicine low and medium dose group and model group Upro content, MDA content was significantly decreased (P lt;0.05), SOD activity was significantly increased (P lt;0.05); the treatment group compared with the model group significantly improved renal function (P lt;0.05). Conclusion Yiqiyangyin Xiaozheng meridians of Chinese medicine may inhibit oxidative stress in diabetic rats to play renal protection. [Keywords:] Qi Yin meridians of Chinese medicine Xiaozheng; diabetic nephropathy; oxidative stress Abstract: ObjectiveTo investigate the effects of supplementing “qi” - nourishing “yin” and disperse blood stasis - dredge collateral herbs on oxidative stress in the kidney of diabetic rats and its mechamisms. MethodsSD rats were randomly divided into 6 groups: Nephrectomy group, model group, irbesatan group, TCM low dose group, TCM middle dose group, and TCM high dose group, and were adminstered with the medicine respectively. In the sixth week, 24 h urine protein (U Pro), renal function, the content of MDA , and the activity of SOD were detected. ResultsIn irbesatan, TCM low dose and middle dose groups, the levels of UPro and MDA were significantly decreased (P lt;0.05), and t