Qing Tang Zhenjing Experimental Study.doc

 PAGE \* MERGEFORMAT 9 Qing Tang Zhenjing Experimental Study [Abstract] Objective To study the Qing Tang Zhenjing, the pharmacological effects of hypnosis. Methods 50 mice were randomly divided into 5 groups, namely saline group, stable group and Qing Tang low, medium and high dose group, stable group were given 0.1 mL / 10 g oral administration, the other 4 groups in accordance with 0.2 mL/10 g ig, spontaneous activity recorded before and after administration to determine sodium pentobarbital given threshold hypnotic dose of sleeping time in mice and Statistics under the threshold dose the number of animals of sleep, the other with convulsive nikethamide mice was observed by the Qing Tang incidence of seizures in mice. Results Qing Tang 3.0,6.0 g / kg dose significantly inhibited the spontaneous activity of mice, extend the threshold dose of sodium pentobarbital sleeping time in mice, an increase of sodium pentobarbital sleep caused by subthreshold hypnotic dose of the number of animals, and significantly against the convulsions induced nikethamide role. Conclusion Qing Tang significant sedative, hypnotic, anticonvulsant effect. [Keywords:] Qing Tang, sedative, hypnotic, anticonvulsant, mice Abstract: Objective To study the pharmacological effects of Qinggong Decoction on sedation and hypnosis. Methods Fifty mice were randomly divided into five groups: NS group, diazepam group, and low-, mid-, high-dose Qinggong Decoction group. Diazepam group was given 0.1 mL/10 g diazepam, and other four groups were given 0.2 mL/10 g corresponding drugs. Spontaneous activities before and after ig. were recorded and the sleeping time of mice with pentobarbital sodium (superthreshold dosage) and the number of the sleeping mice with pentobarbital sodium (subthreshold dosage) were measured. Convulsion model induced by nikethamide was used to observe the change of the seizure rate in mice after given Qinggong Decoction. Results Qinggong Decoction (3.0, 6.0 g / kg) could