Qing Yin on renal protective effect of kidney of diabetic rats and its possible mechanism.doc

 PAGE \* MERGEFORMAT 19 Qing Yin on renal protective effect of kidney of diabetic rats and its possible mechanism Of: Hao Yaning membered Yin Aiping, Yang Shifeng, Yanjun Fei [Abstract] Objective To investigate the renal clearance drink on the kidneys of diabetic rats and possible mechanisms of protection. Methods 40 streptozotocin induced diabetic rats were randomly divided into model group, renal clear drinking group, benazepril group and renal clearance drink combined with benazepril group, observed after 8 weeks of continuous administration blood glucose, kidney function and changes in 24h urine protein were detected in kidney tissue and urine malondialdehyde (MDA), and kidney tissue superoxide dismutase (SOD) activity, serum transforming growth factor (TGF 1) level changes observed by light microscopy of renal pathological changes. Results of the drug group, renal function improved significantly compared with the control group, no significant difference (P gt; 0.05), but blood glucose was not improved effects, 24h urine protein were higher than the model group decreased significantly (P lt;0.05 or P lt;0.01), combination group dropped most significantly (P lt;0.01), the drug in renal tissue and urine MDA content of kidney tissue SOD activity and serum TGF 1 expression and the model group were significantly different (P lt;0.05 or P lt;0.01), the combination group and the other drug group were significant differences (P lt;0.05). Light microscopy of the drug group kidney pathological changes were improved in different degrees, no significant difference among groups. Conclusion kidney kidney of diabetic rats to drink clear protective effect, and benazepril combined with a synergistic effect. The mechanism may be related to inhibition of oxidative stress and enhanced antioxidant capacity and reduce the inflammatory cytokines TGF 1 expression. [Keywords:] Renal clearance drink, diabetic nephropathy, superoxide dismutase, malondialdehyde, transforming