Qizhi Yifei particles on COPD rat model SPA expression and ultrastructure.doc

 PAGE \* MERGEFORMAT 12 Qizhi Yifei particles on COPD rat model SPA expression and ultrastructure OF: Juan Zhang Yi Wei Shu Li Jintian Zhang Li Liu Yongqi [Abstract] Objective Qizhi Yifei particles in chronic obstructive pulmonary disease (COPD) rat model of pulmonary surfactant protein A (SP A) expression in lung tissue ultrastructure. Methods fat intratracheal instillation Add smoked 28 d polysaccharide COPD rat model was established by immunohistochemistry and detected the expression of SP A TEM ultrastructure of alveolar type cells. Results compared with the control group, model group was significantly reduced SP A There were significant differences (P lt;0.01), alveolar type epithelial cell incomplete; with model group, Qizhi Yifei particles treated rats significantly increased the expression of SP A, significant difference (P lt;0.01), alveolar type epithelial cell integrity. Conclusion Qizhi Yifei particles can significantly increase the expression of SP A rat model to improve the cell ultrastructure, the occurrence of COPD play a preventive effect. [Keywords:] Qizhi Yifei particles; COPD; SP A; ultrastructure Chronic obstructive pulmonary disease (COPD) is a kind of airflow obstruction characteristic of chronic bronchitis and (or) emphysema, airflow limitation is not fully reversible, showing progressive development, and the lungs of cigarette smoke and other harmful gases or harmful abnormal inflammatory response of particles (1). The World Health Organization predicts that by 2020 COPD will become the world’s fifth economic burden of disease (2). In our country, in the elderly susceptible to disease, chronic bronchitis and lung Emphysema ranks third, while the fatality rate for the first one (3), the elderly more and more serious health threat to the life, so prevention and treatment of COPD at home and abroad has become a hot topic in academic research. The subject observed through the experimental study of pure Chinese medicine Qizhi