Purine nucleotides in chronic heroin conditioned place preference in rats treated with acute withdrawal of.doc

 PAGE \* MERGEFORMAT 13 Purine nucleotides in chronic heroin conditioned place preference in rats treated with acute withdrawal of Study: Hong Min Li Kun, HE Hai Li Hongmei Liu Jiankai [Abstract] Objective To study the dependence of purine nucleotides on heroin conditioned place preference in rats with acute withdrawal effects. Methods 50 male Wistar rats were randomly divided into control group (normal saline 9 d, heroin group ( intraperitoneal injection of heroin, 9 d, heroin + adenosine monophosphate (AMP) + guanosine monophosphate (GMP) group (intraperitoneal injection of heroin and AMP and GMP 9 d, heroin + AMP group (intraperitoneal injection of heroin and AMP 9 d, heroin + GMP Group (intraperitoneal injection of heroin and GMP 9 d. 0,5,9 days in the first evaluation of the rats conditioned place preference, the rats were observed inside the black box in the place preference of white side (side of the residence time of drugs with . by naloxone on acute withdrawal symptoms were observed and evaluated. Results saline control group 5 d after injection of drugs with side length of stay was significantly shorter, 9 d after injection of further shortening of the side with the Conditions of drugs place aversion, heroin rats 9 d after administration of drugs with side length of stay was significantly prolonged with drugs on the side produced a place preference, heroin + AMP + GMP Group, heroin + AMP group, after administration of heroin + GMP Group side of the drug with no significant extension of stay, indicating that purine nucleotides inhibit the compensation of heroin CPP. heroin, while the role of purine nucleotide and withdrawal in rats, ptosis, teeth chatter and chewing occurred more frequently than heroin alone significantly reduced (P lt;0.05). Conclusion Application of purine nucleotide system in rats can inhibit the spirit of heroin dependence, but also reduce some of its acute withdrawal symptoms. [Keywords:] dependence, purine nucleotides, c