Purslane beet red pigment of anti-tumor experiment.doc

 PAGE \* MERGEFORMAT 15 Purslane beet red pigment of anti-tumor experiment [Abstract] Objective To observe the purslane beet red pigment combined with cyclophosphamide (CTX) of the anti-tumor effect. Methods of mice inoculated with S180 tumor cells into tumor-bearing control group, CTX, purslane beet red pigment (high , medium, low dose) + CTX group. administration of 10 d, the tumor inhibition rate, and peripheral blood cells, bone marrow nucleated cell count, spleen, thymus index, immune globulin, liver and kidney function testing. results tumor-bearing control group, CTX group was significantly inhibited tumor growth. purslane beet red pigment of low, medium and high dose groups combined CTX CTX group was significantly higher tumor inhibition rate. and the control group tumor than a single CTX treated spleen and thymus index, IgA, IgG, IgM levels were significantly lower, WBC, PLT and reduced bone marrow cell count, ALT, BUN increased. purslane different doses of combined CTX treatment beet red pigment, can be improved to varying degrees, spleen and thymus index, IgG, IgM and other indicators of immunity, increase WBC, PLT and bone marrow nucleated cell counts, lower ALT, BUN. Conclusion Machi Xian beet red pigment on the inhibition of sarcoma S180 in mice , resistance to chemotherapy CTX S180 mice attenuated the effect of synergy. [Keywords:] purslane beet red pigment cyclophosphamide S180 tumor in mice Abstract: ObjectiveTo explore the role of betacyanins extracted from Portulaca oleracea L. in the therapeutic effect of cyclophosphamide (CTX) and its side-effect in mice loaded with S180 murine sarcoma cells.MethodsThe mice inoculated with S180 murine sarcoma cells were divided into 5 groups : S180 control group, sc 2 mg / kg d of CTX group, ig betacyanins (250,500 and1000 mg / kg d) + sc CTX groups. After 10-day treatment, the tumor inhibition rate, peripheral blood cells, bone marrow karyocytes , immunoglobulin (Ig), the index of spleen and thy