Radiation brain injury in rabbit model of.doc

 PAGE \* MERGEFORMAT 6 Radiation brain injury in rabbit model of Author: Chen Hua Li Zhiyong Li Qisheng official key Liu Hong-Mei Wang [Abstract] Objective To establish can be used for scientific research in animal models of radiation brain injury. Methods 40 New Zealand rabbits as animal models were randomly divided into four groups: 10Gy, 15Gy, 20Gy and 30Gy groups. Respectively, established under the three-dimensional CT-reconstructed image data, three-dimensional conformal radiation therapy system (3D  TPS) accurate treatment plan designed to optimize the radiation target volume dose distribution, exposure volume of about 1cm * 1cm * 1cm, 6MV X ray single large dose of irradiation. The results of 3D  TPS of the dose distribution curve showed that uniform dose distribution of the exposed area, 95% of the 100% isodose curves enveloping the target area the size of the exposed volume (1 ± 0.03) cm3. Conclusion animal models exposed zone, resulting in dose uniformity, accurate, and can be used to study the radiation brain damage. [Keywords:] Animal model; radiation brain injury; conformal radiation therapy 1 Materials and methods 1.1 Animals and Animal Experimental Center of our school division to provide 40 New Zealand white rabbits, weighing 4 ~ 4.5kg, were randomly divided into four groups: 10Gy, 15Gy, 20Gy and 30Gy groups. 1.2 The main experimental equipment Marconi produced by the United States Picker spiral CT scanner, the German company Leibinger stereotactic frame; Leibinger, and Marconi Corporation 3D TPS workstation; the United States Varian 2100C medical linear accelerator, one Taiwan; my school army Center for Experimental Pathology carbon dioxide incubator, automatic photo-microscope, inverted microscope, temperature, low temperature refrigerators, low-temperature high-speed centrifuge and the slicing machine, the Japanese perspective JBM-1200EX electron microscope, one Taiwan and Japan, Hitachi S-450 scanning electron microscope, one T