Realgar nano-liposome preparation characterization and in vitro anti-tumor effect of.docVIP

 PAGE \* MERGEFORMAT 16 Realgar nano-liposome preparation characterization and in vitro anti-tumor effect of [Abstract] Objective: To study the realgar nano liposome method and test its properties. Methods: Preparation of chemical precipitation nanometer realgar first film distributed realgar nanoparticles prepared by high pressure homogenization liposomes. Using electron microscopy, spectroscopy, atomic fluorescence spectrometer, laser particle size analyzer its characteristics and to study its in vitro anti-tumor cells. Results: The film dispersion prepared by high pressure homogenization realgar nano liposome average size of 102.3 nm , good dispersion, spherical or ovoid. spectrometers confirmed arsenic and sulfur containing composition, liposome drug encapsulation efficiency was 82.78%. HepG2 hepatoma cells in vitro showed inhibition of growth of its good effect. Conclusion: The above method can be successfully prepared liposomes realgar nanometer-scale particle size smaller, in line with the requirements of nano-formulations, good stability, high drug encapsulation, and have a good anti-tumor cells. nanometer realgar fat plasmid is a novel nano-scale formulations of traditional Chinese medicine in the application of anti-tumor provides a new way of thinking. [Keywords:] nano-liposomes, realgar, characteristics; anti-tumor effect In recent years, scholars will be mainly composed of arsenic trioxide (As2O3 arsenic in Chinese medicine for the treatment of acute promyelocytic leukemia, good effect, causing the people from arsenic Cancer Therapeutics great interest perspective. Orpiment and arsenic belong to the same arsenic minerals herbs, the main component of As2S2 and As4S4, and mixed with a small amount of As2O3 and other heavy metal salts. traditional medicine, realgar with detoxification, dampness, phlegm, cut malaria and so on; modern medical studies have shown that realgar also has anti-tumor effect. Previous studies confirmed that in chronic