Recombinant human interleukin11 thrombocytopenia after chemotherapy clinical study.docVIP

 PAGE \* MERGEFORMAT 10 Recombinant human interleukin11 thrombocytopenia after chemotherapy clinical study Study: Song Yi Mei Liao Guoqing Wang Hongmei Liu Peng Hui Qing State Solution [Abstract] Objective of recombinant human interleukin 11 (rhIL 11 treatment of thrombocytopenia of chemotherapy efficacy and toxicity. Methods 62 patients after 1 cycle of chemotherapy platelets 50 109 / L in patients with non randomly divided into treatment group and control group, treatment group 2 cycles of chemotherapy, 24 h after subcutaneous injection of rhIL 11,1.5 mg / second, 1 / d, continuous medication 7 ~ 14 d, or platelet recovery from the lowest point to thegt; = 100 109 / L stop, the control group at the end of 2 cycles of chemotherapy do not accept rhIL 11. platelets after chemotherapy treatment group was significantly higher rise, respectively (72.73 + -0.34 109 / L and ( 13.69 + -6.52 109 / L, there was significant difference (P lt;0.05, treatment group, infusion of platelets need to average (0.29 + -0.58 units, the control group required an average of infused platelets (0.81 + -1.37 units, there was significant difference (P lt;0.01). The main side effects: fatigue, injection site pain, nausea, vomiting, muscle and joint pain, conjunctival congestion, skin rash. Conclusion rhIL 11 to treat chemotherapy-induced thrombocytopenia is an effective and safe treatment of thrombocytopenia drug. [Keywords:] recombinant human interleukin-11, chemotherapy, toxicity, thrombocytopenia IL11 mainly by bone marrow stromal cells, more exciting to hematopoietic stem cells and megakaryocyte cell precursor cell proliferation and differentiation, induced megakaryocytes mature, peripheral platelet increase (1). Tongguo DNA Zhongzu technology production of IL 11 ? recombinant human IL 11 ( rhIL 11, could effectively improve the symptoms of thrombocytopenia, the platelet count and rapid growth, accelerate the cancer patients the right dose of chemotherapy. In this pap