Recurrence after radiotherapy Molecular Mechanism of.docVIP

 PAGE \* MERGEFORMAT 20 Recurrence after radiotherapy Molecular Mechanism of [Abstract] NPC (nasopharyngeal carcinoma, NPC) recurrence after radiotherapy is the main reason for unsuccessful treatment. Radiotherapy-induced DNA damage repair capacity of tumor cells and the different regulation of apoptosis of tumor cells directly affect the sensitivity to radiotherapy. made in recent years, cancer stem cells (TSC) theory is that tumor recurrence, metastasis and resistance to treatment etc, TSC-related. This paper will be radiation-induced DNA damage repair, apoptosis of tumor cells and tumor stem cells in three aspects to recurrence of NPC after radiotherapy machine production are reviewed. [Keywords:] nasopharyngeal carcinoma; radiation therapy; cancer stem cells NPC is one of common malignant tumors in southern China, mainly to radiation therapy, but the effects are not ideal, about 55% of the NPC appears in the 5 years after radiotherapy recurrence. The main reason and the hidden parts of NPC disease, nasopharyngeal Ministry of a complex, than a single treatment, and different pathological types of NPC patients, tumor differentiation, while treatment severity, clinical manifestations, physical status, chemotherapy sensitivity exist in varying degrees of differences. In this paper, the mechanism of radiation sensitivity of NPC are summarized below. 1 DNA damage repair and the recurrence of NPC after radiotherapy 1.1 DNA repair gene radiation can cause DNA strand breaks and DNA-protein cross-linked, eventually leading to cell death. DNA repair capacity of cell survival and death is one of the reasons. hMSH2 is the most studied gene in one of the mismatch repair system. hMSH2 protein to be part of hMutS @ and hMutSβ dimer, DNA replication recognition of mismatched bases and insertion deletion loop, and with the combination of DNA repair is required to complete one of the components [1,2]. Fankai [3] reported that radiation can induce the express