Regarding the kidney meridians granule on blood pressure and renin in spontaneously hypertensive rats - angiotensin system_0.doc

 PAGE \* MERGEFORMAT 8 Regarding the kidney meridians granule on blood pressure and renin in spontaneously hypertensive rats - angiotensin system Of: Moulin Mao, Lian Yuan, National Secretary, Song Mei, Ma Hongbo, Wang study, Cai Pingping [Abstract] Objective To observe the level of different doses of particles kidney meridians blood pressure in spontaneously hypertensive rats (SHR) blood pressure and renin - angiotensin system (RAS). Methods SHR were randomly divided into model group, the Cato Plymouth peace kidney meridians control particles of high blood pressure, low-dose group. normal Wistar rats as control. EXPERIMENTAL required by the same time every day at 1 mL/100 g body weight, respectively, perfusion, and distilled water for 8 weeks. drugs were measured before and weekly blood pressure medication 1,2,4,6,8, and angiotensin (Ang) Ⅰ, Ang Ⅱ and aldosterone (ALD). Results SHR after 8 weeks after treatment, flat kidney meridians buck particles high dose group significantly decreased blood pressure than before treatment, the difference was statistically significant (P lt;0.01). antihypertensive effect of captopril onset of faster, but 2 to 8 weeks, no significant difference between groups (P gt; 0.05), plasma Ang Ⅱ, ALD decreased to ALD decreased significantly (P lt;0.01). show kidney meridians flat particles can be reduced SHR blood pressure, blood pressure, inhibition of RAS activity. Conclusion kidney meridians flat particles have a stable blood pressure to ease hypotensive effect, can reverse the hypertension of early renal damage. [Keywords:] kidney meridians buck flat particles, hypertension; early renal damage in rats Keywords:: Pingshen Tongluo Jiangya granula; hypertension, early stage of renal damage, rat Hypertension is a major worldwide public health problems can lead to cerebral blood vessels, heart and kidney diseases and other important organs of the series, serious harm to human health. The level of renal collaterals observed