Relationship between p53 gene and colorectal cancer research progress.doc

 PAGE \* MERGEFORMAT 20 Relationship between p53 gene and colorectal cancer research progress [Keywords:] p53 gene, colorectal cancer, gene mutation Colorectal cancer is common malignant tumor in China, in recent decades with the improvement of living standards and social structure of the tendency of aging, its incidence tended to increase mortality. Colorectal cancer invasion and metastasis is the cause leading cause of death in patients with serious harm to human health. Over the years in order to explore its pathogenesis, early diagnosis and effective treatment, people were a lot of research work and made some progress. but its causes have not yet fully understood. now than the generally accepted view is that: the generation of colorectal cancer is due to become oncogenes and tumor suppressor genes caused by the synergistic effect of the normal colorectal mucosa initially by the development of a benign epithelial hyperplasia and malignant transformation into adenocarcinoma , , , and then develop into metastases. p53 gene is a tumor suppressor gene, many clinical trials have confirmed p53 gene mutation is closely related to the occurrence of some tumors, and have confirmed that p53 gene mutation and overexpression of p53 protein was good correlation. p53 gene therefore become a research hotspot tumor invasion and metastasis, the author p53 gene and colorectal cancer reviewed the research progress. p53 gene structure and location of the human p53 gene is located on chromosome 17p13.1 total length of 16 ~ 20 kb, contains 11 exons and 10 introns, encoding 393 amino acids, relative molecular mass 53 000 nuclear phosphoprotein. Wt p53 protein can be divided into three parts. The first part includes the transcriptional activation domain and inhibitory domain, located in the amino acid 1 95Aa end, this area is also the p53 and Mdm 2, p14ARF, and p300 binding domain. The second part is identified with the specific DNA sequence binding of 102 292Aa the central c